Published
2022-11-21
Section
Research Article
How to Cite
Designing Polymer-based Mucosa Membranes: Biomimicking
Ekta Jagtiani
Polymer and Surface Coating Technology ICT Mumbai.
DOI: https://doi.org/10.36664/bt/2022/v69i1/172497
Keywords: glycopolymer, mucosa, membranes, collagen, cellulose, hydrogel, buccal.
Abstract
Mucoadhesion develops when a polymer adheres to the mucosal membrane through chemical or physical interactions. Adhesive materials are often employed in the manufacture of dosage forms for transmucosal drug administration via oral, nasal, esophageal, buccal and vaginal routes. This review covers some of the most prevalent synthetic methods for improving the mucoadhesive characteristics of polymeric materials. The buccal film and the oral dose form are two of these administration methods. Medication with a high blood perfusion rate can easily pass through the mucosal barrier of the mouth (oral mucosa). Drugs with low bioavailability and short half-life are simpler to administer. Buccal films, as opposed to traditional drug delivery systems, enable for the regulated and prolonged release of topical pharmaceuticals and are favoured over alternative approaches for delivering medications that are at risk of being lost because to the first pass effect, reduced permeability, enzyme degradation along with the gastrointestinal system's changing environment. Superior mucoadhesive qualities are found in hydrophilic polymers that have charged groups and/or non-ionic functional groups that can establish hydrogen bonds with mucosal surfaces. There are multiple ways for assessing the mucoadhesive characteristics of different dosage formulations. This review provides an overview of the properties of mucoadhesive and mucus gel, as well as the most commonly used procedures.
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References
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