Published
2022-11-21
Section
Review Article
How to Cite
Peptidomimetics: A Synthetic Tool to Treat Alzheimer’s Disease
Shubham Patil
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai.
Pratham Lotia
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai.
DOI: https://doi.org/10.36664/bt/2022/v69i1/172472
Keywords: Peptidomimetics, Alzheimer’s, Amyloid-β, μ receptors, Peptide Stapling.
Abstract
Peptidomimetics is nothing but the modification of the peptide structure by bioisosterism so that there is a significant improvement in the pharmacokinetic properties erstwhile the peptide structure is mimicked in such a way that each building block of a peptidomimetic resembles an amino acid which was the building block for the peptide that was mimicked. Different approaches are used to get a potent and efficient inhibitor by peptide stapling, modifying sequences, and in many other designing ways. Here we are using these approaches to target the amyloid-β receptors by using inhibitors by preventing or breaking the amyloid aggregation.
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